Interventions
Start with the foundations. Then explore the frontier.
Healthy longevity is bigger than a supplement stack. Use familiar foundations to calibrate the evidence for medicines, supplements and experimental geroscience.
Experimental & emerging geroscience
Compounds and therapies already tracked
The original evidence catalog remains intact, including human trials, result interpretation, safety and a separate animal/lab evidence layer.
Experimental geroprotector
17alpha-estradiol
A naturally occurring estrogen-related molecule studied in geroscience after lifespan and metabolic effects were observed in animal models.
Early-stage human evidence
- Human research
- Results
- Safety
Drug / geroscience
Acarbose
A medicine that slows carbohydrate digestion and post-meal glucose rises, studied in geroscience because of lifespan findings in animal models.
1 healthy-aging outcome area tracked
- Human research
3 outcome assessment(s) still require classification.
- Results
- Safety
3 outcome assessment(s) still require classification.
Lifestyle / physiological
Aerobic exercise
Sustained rhythmic exercise such as walking, cycling, running or swimming that raises cardiorespiratory demand and is studied for fitness, function, cardiometabolic health and healthy aging.
Early-stage human evidence
- Human research
- Results
- Safety
Microbiome
Akkermansia muciniphila
A next-generation gut microbe studied in live and pasteurized forms. AgeBeacon tracks 38 registry-linked trials; 2 are directly aging-relevant and 1 is indirect. Direct aging evidence remains too immature for an efficacy score.
Human research is being tracked
- Human research
- Results
- Safety
Longevity compound
Alpha-ketoglutarate (AKG)
A normal cellular metabolite involved in energy production and enzyme regulation, studied for possible effects on inflammation and aging-related biology.
Human research is being tracked
- Human research
- Results
- Safety
Longevity compound
Berberine
A plant-derived compound being studied for effects on glucose and lipid metabolism and cellular energy-sensing pathways.
Early-stage human evidence
- Human research
- Results
- Safety
Senolytic candidate
Dasatinib + Quercetin
An experimental senolytic combination being studied for whether clearing some senescent cells can improve age-related function.
4 healthy-aging outcome areas tracked
- Human research
3 outcome assessment(s) still require classification.
- Results
- Safety
3 outcome assessment(s) still require classification.
Longevity peptide
Epitalon / Epithalon
A synthetic peptide investigated in aging research, with limited controlled human evidence for longevity-related claims.
Early-stage human evidence
- Human research
- Results
- Safety
Microbiome
Fecal microbiota transplantation (FMT)
Transfer of a screened donor gut microbial community into a recipient. AgeBeacon tracks human evidence relevant to aging and healthspan separately from established or investigational disease-specific uses.
Human research is being tracked
- Human research
- Results
- Safety
Senolytic candidate
Fisetin
A plant flavonoid being investigated for senolytic activity and its potential effects on age-related cellular dysfunction.
1 healthy-aging outcome area tracked
- Human research
3 outcome assessment(s) still require classification.
- Results
- Safety
3 outcome assessment(s) still require classification.
Longevity compound
GlyNAC
A combination of glycine and N-acetylcysteine studied as precursors for glutathione and for effects on oxidative stress, mitochondrial function and healthy aging.
Early-stage human evidence
- Human research
- Results
- Safety
Drug / geroscience
Lithium
A medicine and naturally occurring element being studied at different exposure levels for effects on cellular signaling, brain health and aging biology.
4 healthy-aging outcome areas tracked
- Human research
10 outcome assessment(s) still require classification.
- Results
- Safety
10 outcome assessment(s) still require classification.
Cell / regenerative
Mesenchymal stromal cells (MSCs)
Mesenchymal stromal/stem-cell products studied for frailty, physical function and age-related disease contexts.
Human research is being tracked
- Human research
- Results
- Safety
Drug / geroscience
Metformin
A widely used diabetes medicine being studied for whether its metabolic effects may influence aging-related health beyond glucose control.
7 healthy-aging outcome areas tracked
- Human research
11 outcome assessment(s) still require classification.
- Results
- Safety
11 outcome assessment(s) still require classification.
Longevity compound
NAD+
A central cellular coenzyme involved in energy metabolism, DNA repair and stress responses, studied because NAD biology changes with age.
6 healthy-aging outcome areas tracked
- Human research
50 outcome assessment(s) still require classification.
- Results
- Safety
50 outcome assessment(s) still require classification.
Longevity compound
Nicotinamide riboside (NR)
A vitamin B3-derived NAD+ precursor being studied for effects on cellular energy metabolism and age-related physiology.
5 healthy-aging outcome areas tracked
- Human research
4 outcome assessment(s) still require classification.
- Results
- Safety
4 outcome assessment(s) still require classification.
Longevity compound
NMN
A precursor used by cells to make NAD+, studied for whether changing NAD metabolism can influence age-related physiology.
Human research is being tracked
- Human research
- Results
- Safety
Gene / epigenetic
Partial epigenetic reprogramming
Experimental transient expression of reprogramming factors intended to alter epigenetic state without full dedifferentiation.
Early-stage human evidence
- Human research
- Results
- Safety
Device / physical
Photobiomodulation
Red or near-infrared light interventions studied for physical, cognitive and metabolic outcomes.
Human research is being tracked
- Human research
- Results
- Safety
Microbiome
Prebiotics
Fibers and related substrates that feed gut microbes. AgeBeacon tracks 901 registry-linked trials; 10 are directly aging-relevant and 44 are indirect. No direct healthy-aging efficacy result is ready to score.
Human research is being tracked
- Human research
- Results
- Safety
Microbiome
Probiotics
Live microorganisms studied for effects on the gut ecosystem. AgeBeacon tracks 500 registry-linked trials; 1 is directly aging-relevant and 14 are indirect. Evidence remains strain- and formulation-specific, with no direct healthy-aging efficacy result ready to score.
Early-stage human evidence
- Human research
- Results
- Safety
Longevity compound
Pterostilbene
A resveratrol-related polyphenol being studied for effects on metabolism, inflammation and cellular stress responses.
Human research is being tracked
- Human research
- Results
- Safety
Senolytic candidate
Quercetin
A common plant flavonoid studied in longevity research, including as part of experimental senolytic combinations.
4 healthy-aging outcome areas tracked
- Human research
3 outcome assessment(s) still require classification.
- Results
- Safety
3 outcome assessment(s) still require classification.
Drug / geroscience
Rapamycin (sirolimus)
mTOR inhibitor being studied for effects on aging biology and healthspan-related outcomes.
1 healthy-aging outcome area tracked
- Human research
7 outcome assessment(s) still require classification.
- Results
- Safety
7 outcome assessment(s) still require classification.
Lifestyle / physiological
Resistance training
Progressive exercise using external load, body weight or machines to increase muscular strength, power and related physical function.
Early-stage human evidence
- Human research
- Results
- Safety
Longevity compound
Resveratrol
A plant polyphenol studied for effects on nutrient sensing, metabolism and cellular stress-response pathways associated with aging.
5 healthy-aging outcome areas tracked
- Human research
17 outcome assessment(s) still require classification.
- Results
- Safety
17 outcome assessment(s) still require classification.
Longevity compound
Spermidine
A naturally occurring polyamine being studied for effects on autophagy, cellular maintenance and healthy aging.
Human research is being tracked
- Human research
- Results
- Safety
Microbiome
Synbiotics
Combinations of live microbes and substrates intended to support them. AgeBeacon tracks 209 registry-linked trials; 2 are directly aging-relevant and 10 are indirect. No direct healthy-aging efficacy result is ready to score.
Human research is being tracked
- Human research
- Results
- Safety
Longevity compound
Taurine
A naturally occurring molecule being studied for its relationship to metabolic health, cellular function and age-related changes.
1 healthy-aging outcome area tracked
- Human research
- Results
- Safety
Blood & plasma
Therapeutic plasma exchange / plasma dilution
Blood- and plasma-based procedures that remove, replace or dilute circulating plasma components. AgeBeacon tracks human evidence relevant to aging separately from established disease-specific uses of therapeutic plasma exchange.
1 healthy-aging outcome area tracked
- Human research
- Results
- Safety
Longevity compound
Urolithin A
A gut-microbiome-derived metabolite being studied for mitophagy, mitochondrial quality control and muscle function with age.
Human research is being tracked
- Human research
- Results
- Safety
Evidence maturity is not a benefit ranking. Population, outcome and study design matter. How we interpret evidence.