What Works
What looks promising — and how strong is the evidence?
See where human research is producing signals, where evidence is still emerging, and which questions remain open. Promising is not the same as proven.
Research depth tells us where scientists have learned the most. Results tell us what those studies found. We keep the two separate. Read how we evaluate evidence.
Living longer
Drug / geroscience
Lithium
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Living longer
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 0 remain unknown.
Drug / geroscience
Rapamycin (sirolimus)
mTOR inhibitor being studied for effects on aging biology and healthspan-related outcomes.
1 healthy-aging outcome area tracked
- Human research
- Signal · Living longer
- Safety
4 result(s) are linked, but direction remains unknown.
Physical function
Senolytic candidate
Dasatinib + Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
5 result(s) are linked, but direction remains unknown.
Drug / geroscience
Lithium
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 0 remain unknown.
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
0 beneficial, 1 neutral, 1 harmful and 0 mixed interpreted result(s); 2 remain unknown.
Longevity compound
NAD+
Automated longevity evidence pipeline intervention.
6 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
10 result(s) are linked, but direction remains unknown.
Longevity compound
Nicotinamide riboside (NR)
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
2 beneficial, 2 neutral, 0 harmful and 0 mixed interpreted result(s); 1 remain unknown.
Senolytic candidate
Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
5 result(s) are linked, but direction remains unknown.
Longevity compound
Resveratrol
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Physical function
- Safety
6 result(s) are linked, but direction remains unknown.
Muscle
Drug / geroscience
Acarbose
Automated longevity evidence pipeline intervention.
1 healthy-aging outcome area tracked
- Human research
- Signal · Muscle
- Safety
1 result(s) are linked, but direction remains unknown.
Senolytic candidate
Dasatinib + Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Muscle
- Safety
1 result(s) are linked, but direction remains unknown.
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Muscle
- Safety
0 beneficial, 2 neutral, 0 harmful and 0 mixed interpreted result(s); 2 remain unknown.
Longevity compound
NAD+
Automated longevity evidence pipeline intervention.
6 healthy-aging outcome areas tracked
- Human research
- Signal · Muscle
- Safety
4 result(s) are linked, but direction remains unknown.
Longevity compound
Nicotinamide riboside (NR)
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Muscle
- Safety
4 result(s) are linked, but direction remains unknown.
Senolytic candidate
Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Muscle
- Safety
1 result(s) are linked, but direction remains unknown.
Longevity compound
Resveratrol
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Muscle
- Safety
8 result(s) are linked, but direction remains unknown.
Cognition
Senolytic candidate
Dasatinib + Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
8 result(s) are linked, but direction remains unknown.
Drug / geroscience
Lithium
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
2 result(s) are linked, but direction remains unknown.
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
1 result(s) are linked, but direction remains unknown.
Longevity compound
NAD+
Automated longevity evidence pipeline intervention.
6 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
10 result(s) are linked, but direction remains unknown.
Longevity compound
Nicotinamide riboside (NR)
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
11 result(s) are linked, but direction remains unknown.
Senolytic candidate
Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
8 result(s) are linked, but direction remains unknown.
Longevity compound
Resveratrol
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Cognition
- Safety
2 result(s) are linked, but direction remains unknown.
Longevity compound
Taurine
Automated longevity evidence pipeline intervention.
1 healthy-aging outcome area tracked
- Human research
- Signal · Cognition
- Safety
2 result(s) are linked, but direction remains unknown.
Energy & endurance
Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.
Metabolic health
Drug / geroscience
Lithium
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Metabolic health
- Safety
1 result(s) are linked, but direction remains unknown.
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Metabolic health
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 2 remain unknown.
Longevity compound
NAD+
Automated longevity evidence pipeline intervention.
6 healthy-aging outcome areas tracked
- Human research
- Signal · Metabolic health
- Safety
5 result(s) are linked, but direction remains unknown.
Longevity compound
Resveratrol
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Metabolic health
- Safety
5 result(s) are linked, but direction remains unknown.
Cardiovascular
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Cardiovascular
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 1 remain unknown.
Longevity compound
NAD+
Automated longevity evidence pipeline intervention.
6 healthy-aging outcome areas tracked
- Human research
- Signal · Cardiovascular
- Safety
5 result(s) are linked, but direction remains unknown.
Longevity compound
Nicotinamide riboside (NR)
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Cardiovascular
- Safety
6 result(s) are linked, but direction remains unknown.
Longevity compound
Resveratrol
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Cardiovascular
- Safety
3 result(s) are linked, but direction remains unknown.
Inflammation
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Inflammation
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 1 remain unknown.
Longevity compound
NAD+
Automated longevity evidence pipeline intervention.
6 healthy-aging outcome areas tracked
- Human research
- Signal · Inflammation
- Safety
2 result(s) are linked, but direction remains unknown.
Longevity compound
Nicotinamide riboside (NR)
Automated longevity evidence pipeline intervention.
5 healthy-aging outcome areas tracked
- Human research
- Signal · Inflammation
- Safety
2 result(s) are linked, but direction remains unknown.
Biological aging
Senolytic candidate
Dasatinib + Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Biological aging
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 5 remain unknown.
Senolytic candidate
Fisetin
Automated longevity evidence pipeline intervention.
1 healthy-aging outcome area tracked
- Human research
- Signal · Biological aging
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 0 remain unknown.
Drug / geroscience
Metformin
Automated longevity evidence pipeline intervention.
7 healthy-aging outcome areas tracked
- Human research
- Signal · Biological aging
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 1 remain unknown.
Senolytic candidate
Quercetin
Automated longevity evidence pipeline intervention.
4 healthy-aging outcome areas tracked
- Human research
- Signal · Biological aging
- Safety
0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 5 remain unknown.
Earlier-stage science: biomarkers and mechanisms
These findings can point toward interesting biology and future directions, but they are not yet demonstrated health benefits in humans.
No earlier-stage biomarker or mechanistic findings are currently linked here.