What Works

What looks promising — and how strong is the evidence?

See where human research is producing signals, where evidence is still emerging, and which questions remain open. Promising is not the same as proven.

Research depth tells us where scientists have learned the most. Results tell us what those studies found. We keep the two separate. Read how we evaluate evidence.

Living longer

Drug / geroscience

Lithium

A medicine and naturally occurring element being studied at different exposure levels for effects on cellular signaling, brain health and aging biology.

4 healthy-aging outcome areas tracked

Human research: 10 outcome assessment(s) still require classification.
Signal · Living longer
Safety

10 outcome assessment(s) still require classification.

0 beneficial, 1 neutral, 0 harmful and 0 mixed interpreted result(s); 0 remain unknown. Counts describe linked results, not effect size or certainty.

Drug / geroscience

Rapamycin (sirolimus)

mTOR inhibitor being studied for effects on aging biology and healthspan-related outcomes.

1 healthy-aging outcome area tracked

Human research: 7 outcome assessment(s) still require classification.
Signal · Living longer
Safety

7 outcome assessment(s) still require classification.

4 result(s) are linked, but direction remains unknown.

Physical function

Senolytic candidate

Dasatinib + Quercetin

An experimental senolytic combination being studied for whether clearing some senescent cells can improve age-related function.

4 healthy-aging outcome areas tracked

Human research: 3 outcome assessment(s) still require classification.
Signal · Physical function
Safety

3 outcome assessment(s) still require classification.

5 result(s) are linked, but direction remains unknown.

Drug / geroscience

Metformin

A widely used diabetes medicine being studied for whether its metabolic effects may influence aging-related health beyond glucose control.

7 healthy-aging outcome areas tracked

Human research: 11 outcome assessment(s) still require classification.
Signal · Physical function
Safety

11 outcome assessment(s) still require classification.

0 beneficial, 1 neutral, 1 harmful and 0 mixed interpreted result(s); 2 remain unknown. Counts describe linked results, not effect size or certainty.

Longevity compound

NAD+

A central cellular coenzyme involved in energy metabolism, DNA repair and stress responses, studied because NAD biology changes with age.

6 healthy-aging outcome areas tracked

Human research: 50 outcome assessment(s) still require classification.
Signal · Physical function
Safety

50 outcome assessment(s) still require classification.

10 result(s) are linked, but direction remains unknown.

Longevity compound

Nicotinamide riboside (NR)

A vitamin B3-derived NAD+ precursor being studied for effects on cellular energy metabolism and age-related physiology.

5 healthy-aging outcome areas tracked

Human research: 4 outcome assessment(s) still require classification.
Signal · Physical function
Safety

4 outcome assessment(s) still require classification.

2 beneficial, 2 neutral, 0 harmful and 0 mixed interpreted result(s); 1 remain unknown. Counts describe linked results, not effect size or certainty.

Senolytic candidate

Quercetin

A common plant flavonoid studied in longevity research, including as part of experimental senolytic combinations.

4 healthy-aging outcome areas tracked

Human research: 3 outcome assessment(s) still require classification.
Signal · Physical function
Safety

3 outcome assessment(s) still require classification.

5 result(s) are linked, but direction remains unknown.

Muscle

Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.

Cognition

Senolytic candidate

Dasatinib + Quercetin

An experimental senolytic combination being studied for whether clearing some senescent cells can improve age-related function.

4 healthy-aging outcome areas tracked

Human research: 3 outcome assessment(s) still require classification.
Signal · Cognition
Safety

3 outcome assessment(s) still require classification.

8 result(s) are linked, but direction remains unknown.

Drug / geroscience

Lithium

A medicine and naturally occurring element being studied at different exposure levels for effects on cellular signaling, brain health and aging biology.

4 healthy-aging outcome areas tracked

Human research: 10 outcome assessment(s) still require classification.
Signal · Cognition
Safety

10 outcome assessment(s) still require classification.

2 result(s) are linked, but direction remains unknown.

Drug / geroscience

Metformin

A widely used diabetes medicine being studied for whether its metabolic effects may influence aging-related health beyond glucose control.

7 healthy-aging outcome areas tracked

Human research: 11 outcome assessment(s) still require classification.
Signal · Cognition
Safety

11 outcome assessment(s) still require classification.

1 result(s) are linked, but direction remains unknown.

Longevity compound

NAD+

A central cellular coenzyme involved in energy metabolism, DNA repair and stress responses, studied because NAD biology changes with age.

6 healthy-aging outcome areas tracked

Human research: 50 outcome assessment(s) still require classification.
Signal · Cognition
Safety

50 outcome assessment(s) still require classification.

10 result(s) are linked, but direction remains unknown.

Longevity compound

Nicotinamide riboside (NR)

A vitamin B3-derived NAD+ precursor being studied for effects on cellular energy metabolism and age-related physiology.

5 healthy-aging outcome areas tracked

Human research: 4 outcome assessment(s) still require classification.
Signal · Cognition
Safety

4 outcome assessment(s) still require classification.

11 result(s) are linked, but direction remains unknown.

Senolytic candidate

Quercetin

A common plant flavonoid studied in longevity research, including as part of experimental senolytic combinations.

4 healthy-aging outcome areas tracked

Human research: 3 outcome assessment(s) still require classification.
Signal · Cognition
Safety

3 outcome assessment(s) still require classification.

8 result(s) are linked, but direction remains unknown.

Longevity compound

Resveratrol

A plant polyphenol studied for effects on nutrient sensing, metabolism and cellular stress-response pathways associated with aging.

5 healthy-aging outcome areas tracked

Human research: 17 outcome assessment(s) still require classification.
Signal · Cognition
Safety

17 outcome assessment(s) still require classification.

2 result(s) are linked, but direction remains unknown.

Longevity compound

Taurine

A naturally occurring molecule being studied for its relationship to metabolic health, cellular function and age-related changes.

1 healthy-aging outcome area tracked

Human research
Signal · Cognition
Safety

2 result(s) are linked, but direction remains unknown.

Energy & endurance

Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.

Metabolic health

Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.

Cardiovascular

Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.

Inflammation

Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.

Biological aging

Human research exists, but there is not yet enough interpretable evidence to show a clear signal for this outcome.

Measurements and outcomes requiring more context

Read each endpoint in context. Measurements and unresolved outcome types do not establish meaningful health benefits by themselves.

Drug / geroscience

Acarbose

A medicine that slows carbohydrate digestion and post-meal glucose rises, studied in geroscience because of lifespan findings in animal models.

1 healthy-aging outcome area tracked

Human research: 3 outcome assessment(s) still require classification.
Results
Safety

3 outcome assessment(s) still require classification.

Senolytic candidate

Dasatinib + Quercetin

An experimental senolytic combination being studied for whether clearing some senescent cells can improve age-related function.

4 healthy-aging outcome areas tracked

Human research: 3 outcome assessment(s) still require classification.
Results
Safety

3 outcome assessment(s) still require classification.

Senolytic candidate

Fisetin

A plant flavonoid being investigated for senolytic activity and its potential effects on age-related cellular dysfunction.

1 healthy-aging outcome area tracked

Human research: 3 outcome assessment(s) still require classification.
Results
Safety

3 outcome assessment(s) still require classification.

Drug / geroscience

Lithium

A medicine and naturally occurring element being studied at different exposure levels for effects on cellular signaling, brain health and aging biology.

4 healthy-aging outcome areas tracked

Human research: 10 outcome assessment(s) still require classification.
Results
Safety

10 outcome assessment(s) still require classification.

Drug / geroscience

Metformin

A widely used diabetes medicine being studied for whether its metabolic effects may influence aging-related health beyond glucose control.

7 healthy-aging outcome areas tracked

Human research: 11 outcome assessment(s) still require classification.
Results
Safety

11 outcome assessment(s) still require classification.

Longevity compound

NAD+

A central cellular coenzyme involved in energy metabolism, DNA repair and stress responses, studied because NAD biology changes with age.

6 healthy-aging outcome areas tracked

Human research: 50 outcome assessment(s) still require classification.
Results
Safety

50 outcome assessment(s) still require classification.

Longevity compound

Nicotinamide riboside (NR)

A vitamin B3-derived NAD+ precursor being studied for effects on cellular energy metabolism and age-related physiology.

5 healthy-aging outcome areas tracked

Human research: 4 outcome assessment(s) still require classification.
Results
Safety

4 outcome assessment(s) still require classification.

Senolytic candidate

Quercetin

A common plant flavonoid studied in longevity research, including as part of experimental senolytic combinations.

4 healthy-aging outcome areas tracked

Human research: 3 outcome assessment(s) still require classification.
Results
Safety

3 outcome assessment(s) still require classification.

Longevity compound

Resveratrol

A plant polyphenol studied for effects on nutrient sensing, metabolism and cellular stress-response pathways associated with aging.

5 healthy-aging outcome areas tracked

Human research: 17 outcome assessment(s) still require classification.
Results
Safety

17 outcome assessment(s) still require classification.

Blood & plasma

Therapeutic plasma exchange / plasma dilution

Blood- and plasma-based procedures that remove, replace or dilute circulating plasma components. AgeBeacon tracks human evidence relevant to aging separately from established disease-specific uses of therapeutic plasma exchange.

1 healthy-aging outcome area tracked

Human research
Results
Safety