Your healthy-aging goal
What has actually been shown to help muscle function?
Muscle strength, muscle mass and physical performance in older adults. We separate measured strength from biomarker changes.
Follow the signal, understand the certainty
Some ideas are promising, some are early, and some have disappointed. We show Evidence, Results and Safety separately so you can see both the possibility and the uncertainty — see how we weigh evidence.
Studied without a demonstrated benefit
Human studies have looked at this outcome but the interpreted results shown here have not demonstrated a benefit.
Listed alphabetically — not ranked
Outcome type unresolved — does not establish a health benefit
Drug / geroscience
Metformin
A widely used diabetes medicine being studied for whether its metabolic effects may influence aging-related health beyond glucose control.
7 healthy-aging outcome areas tracked
- Human research
11 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
11 outcome assessment(s) still require classification.
0 beneficial, 2 neutral, 0 harmful and 0 mixed interpreted result(s); 2 remain unknown. Counts describe linked results, not effect size or certainty.
Still being studied
The human evidence is too sparse or unresolved to judge this outcome yet.
Listed alphabetically — not ranked
Outcome type unresolved — does not establish a health benefit
Drug / geroscience
Acarbose
A medicine that slows carbohydrate digestion and post-meal glucose rises, studied in geroscience because of lifespan findings in animal models.
1 healthy-aging outcome area tracked
- Human research
3 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
3 outcome assessment(s) still require classification.
1 result(s) are linked, but direction remains unknown.
Outcome type unresolved — does not establish a health benefit
Senolytic candidate
Dasatinib + Quercetin
An experimental senolytic combination being studied for whether clearing some senescent cells can improve age-related function.
4 healthy-aging outcome areas tracked
- Human research
3 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
3 outcome assessment(s) still require classification.
1 result(s) are linked, but direction remains unknown.
Outcome type unresolved — does not establish a health benefit
Longevity compound
NAD+
A central cellular coenzyme involved in energy metabolism, DNA repair and stress responses, studied because NAD biology changes with age.
6 healthy-aging outcome areas tracked
- Human research
50 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
50 outcome assessment(s) still require classification.
4 result(s) are linked, but direction remains unknown.
Outcome type unresolved — does not establish a health benefit
Longevity compound
Nicotinamide riboside (NR)
A vitamin B3-derived NAD+ precursor being studied for effects on cellular energy metabolism and age-related physiology.
5 healthy-aging outcome areas tracked
- Human research
4 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
4 outcome assessment(s) still require classification.
4 result(s) are linked, but direction remains unknown.
Outcome type unresolved — does not establish a health benefit
Senolytic candidate
Quercetin
A common plant flavonoid studied in longevity research, including as part of experimental senolytic combinations.
4 healthy-aging outcome areas tracked
- Human research
3 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
3 outcome assessment(s) still require classification.
1 result(s) are linked, but direction remains unknown.
Outcome type unresolved — does not establish a health benefit
Longevity compound
Resveratrol
A plant polyphenol studied for effects on nutrient sensing, metabolism and cellular stress-response pathways associated with aging.
5 healthy-aging outcome areas tracked
- Human research
17 outcome assessment(s) still require classification.
- Signal · Muscle
- Safety
17 outcome assessment(s) still require classification.
8 result(s) are linked, but direction remains unknown.