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Blood & plasma

Therapeutic plasma exchange / plasma dilution

Blood- and plasma-based procedures that remove, replace or dilute circulating plasma components. AgeBeacon tracks human evidence relevant to aging separately from established disease-specific uses of therapeutic plasma exchange.

Where the science stands

This page summarizes the current human evidence captured in the Longevity Compass database. Result interpretation is conservative and unresolved outcomes remain unknown.

Evidence depth 28 / 100

Research path

From biological idea to human evidence

These stages show different kinds of evidence for Therapeutic plasma exchange / plasma dilution. Moving through them does not mean an intervention is proven to slow aging.

  1. 1

    Biological idea

    Reviewing animal and laboratory research…

  2. 2

    Human testing

    5 direct aging trial links and 7 related trial links tracked. A trial count describes research activity, not benefit.

  3. 3

    What results show

    0 beneficial, 0 neutral and 0 harmful result links interpreted; 0 remain unresolved.

  4. 4

    Still unanswered

    Whether these findings translate into meaningful, lasting healthy-aging benefits in people remains unproven. Longer follow-up and clearer safety and clinical outcomes are needed.

How AgeBeacon evaluates evidence →

Beyond human trials

The bigger longevity story

Loading animal and laboratory evidence…

Animal and cell studies help explain biological plausibility and identify promising directions. They are shown separately and do not increase the human evidence-depth score.

Research depth

Human evidence picture

Evidence depth describes how much relevant human research exists; it is not an efficacy score. Unknown results are not treated as neutral.

5
Direct aging trials
7
Indirect relevant trials
0
Publications linked
0
Results publications

Interpreted results

Beneficial
0
Neutral
0
Harmful
0
Unknown / unresolved
0

Population relevance

Healthy / aging
0
Disease-specific
0

Safety evidence

0

Trials currently identified with safety-result data.

Go to the source

Studies & publications

Inspect the original evidence behind this profile. Links open the trial registry, PubMed or the publication DOI.

Human Albumin Combined With Plasma Exchange for Frailty InterventionNCT07836127INTERVENTIONAL · NA · 34 participants · NOT_YET_RECRUITINGPlasmapheresis for Treatment of Age-Related FrailtyNCT05054894INTERVENTIONAL · EARLY_PHASE1 · 100 participants · UNKNOWNThe Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And EpigeneticsNCT06534450INTERVENTIONAL · PHASE3 · 40 participants · UNKNOWNEffects of Plasmapheresis on Aging BiomarkersNCT05004220OBSERVATIONAL · 41 participants · COMPLETEDStudy of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years OldNCT04897113INTERVENTIONAL · NA · 80 participants · UNKNOWNSafety and Efficacy of Plasma Transfusion From Exercise-trained Donors in Patients With Early Alzheimer's DiseaseNCT05068830INTERVENTIONAL · PHASE2 · 60 participants · ACTIVE_NOT_RECRUITINGPlasma Dilution and Infusion to Improve Cognition in Mild Cognitive Impairment (MCI)NCT06234436INTERVENTIONAL · EARLY_PHASE1 · 10 participants · UNKNOWNPlasma Exchange With Albumin in AMN PatientsNCT04303416INTERVENTIONAL · PHASE2/PHASE3 · 5 participants · COMPLETEDEfficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal FluidNCT00742417INTERVENTIONAL · PHASE2 · 42 participants · COMPLETEDImpact of Therapeutic Plasma Exchange on RNA Biomarker Expression Levels in Alzheimer's PatientsNCT06079827OBSERVATIONAL · 43 participants · UNKNOWNPlasmapheresis Versus Plasma Infusion from Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease ProgressionNCT03887741INTERVENTIONAL · PHASE1 · 3 participants · COMPLETEDA Study to Evaluate Albumin and Immunoglobulin in Alzheimer's DiseaseNCT01561053INTERVENTIONAL · PHASE2/PHASE3 · 347 participants · COMPLETED

The big unanswered question

Can promising biology translate into meaningful healthy-aging benefits?

That is the standard this evidence profile is tracking. New trials and results can strengthen, weaken or change the picture over time.

Confidence: lowScore model: v1.0-publication-candidateUpdated: 2026-09-30Source: live evidence database