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Longevity compound

Urolithin A

Automated longevity evidence pipeline intervention.

Where the science stands

This page summarizes the current human evidence captured in the Longevity Compass database. Result interpretation is conservative and unresolved outcomes remain unknown.

Evidence depth 67 / 100

Research path

From biological idea to human evidence

These stages show different kinds of evidence for Urolithin A. Moving through them does not mean an intervention is proven to slow aging.

  1. 1

    Biological idea

    Reviewing animal and laboratory research…

  2. 2

    Human testing

    9 direct aging trial links and 4 related trial links tracked. A trial count describes research activity, not benefit.

  3. 3

    What results show

    0 beneficial, 0 neutral and 0 harmful result links interpreted; 0 remain unresolved.

  4. 4

    Still unanswered

    Whether these findings translate into meaningful, lasting healthy-aging benefits in people remains unproven. Longer follow-up and clearer safety and clinical outcomes are needed.

How AgeBeacon evaluates evidence →

Beyond human trials

The bigger longevity story

Loading animal and laboratory evidence…

Animal and cell studies help explain biological plausibility and identify promising directions. They are shown separately and do not increase the human evidence-depth score.

Research depth

Human evidence picture

Evidence depth describes how much relevant human research exists; it is not an efficacy score. Unknown results are not treated as neutral.

9
Direct aging trials
4
Indirect relevant trials
3
Publications linked
1
Results publications

Interpreted results

Beneficial
0
Neutral
0
Harmful
0
Unknown / unresolved
0

Population relevance

Healthy / aging
7
Disease-specific
0

Safety evidence

0

Trials currently identified with safety-result data.

Go to the source

Studies & publications

Inspect the original evidence behind this profile. Links open the trial registry, PubMed or the publication DOI.

Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging BiomarkersNCT06990256INTERVENTIONAL · NA · 83 participants · ACTIVE_NOT_RECRUITINGPRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)NCT07451496INTERVENTIONAL · NA · 20 participants · RECRUITINGImpact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older AdultsNCT06556706INTERVENTIONAL · NA · 26 participants · COMPLETEDInfluence of the Urolithin A on the Population With BMI Higher Than 30 During Restricted Eating.NCT07377136INTERVENTIONAL · NA · 100 participants · ENROLLING_BY_INVITATIONOral Supplementation During PR Participation in COPDNCT06324214INTERVENTIONAL · PHASE2 · 10 participants · UNKNOWNThe Mitopure Challenge to Detect Levels of Urolithin A in Dried Blood SpotsNCT04985630INTERVENTIONAL · NA · 250 participants · RECRUITINGMitopure™ (Proprietary Urolithin A) Bioavailability in Healthy AdultsNCT04160312INTERVENTIONAL · NA · 100 participants · COMPLETEDThe Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged AdultsNCT07231783INTERVENTIONAL · NA · 120 participants · RECRUITINGEvaluation of the Anti-aging Efficacy of One Face Care Cosmetic ProductNCT06619457INTERVENTIONAL · NA · 36 participants · COMPLETEDThe Effects of Protein Supplementation With or Without Urolithin A During Single-leg ImmobilizationNCT05814705INTERVENTIONAL · NA · 24 participants · ACTIVE_NOT_RECRUITINGUrolithin A Supplementation to Boost Immune HealthNCT05735886INTERVENTIONAL · NA · 50 participants · COMPLETEDEffects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical TrialNCT06274749INTERVENTIONAL · NA · 180 participants · RECRUITINGDenk D, Singh A, Kasler HG, D'Amico D, Rey J, Alcober-Boquet L, Gorol JM, Steup C, Tiwari R, Kwok R, Arguello RJ, Faitg J, Sprinzl K, Zeuzem S, Nekljudova V, Loibl S, Verdin E, Rinsch C, Greten FR. Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. Nat Aging. 2025 Nov;5(11):2309-2322. doi: 10.1038/s43587-025-00996-x. Epub 2025 Oct 31.PMID 41174221Results publicationLiu S, D'Amico D, Shankland E, Bhayana S, Garcia JM, Aebischer P, Rinsch C, Singh A, Marcinek DJ. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022 Jan 4;5(1):e2144279. doi: 10.1001/jamanetworkopen.2021.44279.PMID 35050355Linked publicationSingh A, D'Amico D, Andreux PA, Dunngalvin G, Kern T, Blanco-Bose W, Auwerx J, Aebischer P, Rinsch C. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022 Feb;76(2):297-308. doi: 10.1038/s41430-021-00950-1. Epub 2021 Jun 11.PMID 34117375Linked publication

The big unanswered question

Can promising biology translate into meaningful healthy-aging benefits?

That is the standard this evidence profile is tracking. New trials and results can strengthen, weaken or change the picture over time.

Confidence: lowScore model: v0.5-curated-ruleUpdated: 2026-09-21Source: live evidence database