Microbiome
Short-chain fatty acids
Microbial and host metabolites including acetate, propionate and butyrate.
What it measures
Concentrations of short-chain fatty acids produced largely from microbial fermentation.
Why it matters
Important in gut physiology and studied in metabolic and immune health.
How to interpret it
Compartment matters: stool concentrations do not directly equal production or systemic exposure.
Important limitations
Sampling, diet and analytical methods strongly affect values; clinical longevity targets are not established.
Evidence status
Research-stage biomarker
Mechanistically relevant research biomarkers with limited standardized consumer interpretation.
Research & guidance
Original papers, validation studies, reviews and clinical guidance connected to this measurement.
systematic review / meta-analysis
The impact of ageing on faecal short chain fatty acids levels in apparently healthy adults: A systematic review and meta-analysis
Ageing Research Reviews · 2026
Older adults had lower fecal acetate, propionate, butyrate and total SCFAs on average; substantial methodological and lifestyle heterogeneity remains.
systematic review / meta-analysis of RCTs
Effects of Polyphenol Supplementation on Gut Microbiota Composition and Fecal Short-Chain Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients · 2026
Fecal SCFAs can change after dietary interventions, but fecal concentrations do not directly measure systemic exposure or prove health benefit.
For education and evidence exploration, not diagnosis or individualized medical advice.