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Biological aging
PhenoAge
Research-stage biomarkerComposite/epigenetic ageBloodyears
A biological-age construct developed from clinical chemistry and later DNA methylation.
What it measures
A mortality-oriented phenotypic-age model and related methylation implementation.
Why it matters
Associated with morbidity and mortality in cohort studies.
How to interpret it
Distinguish clinical Phenotypic Age from DNAm PhenoAge implementations.
Important limitations
Not an approved surrogate endpoint for longevity interventions.
Evidence status
Research-stage biomarker
Useful research aging measure with outcome associations.
Research & guidance
Original papers, validation studies, reviews and clinical guidance connected to this measurement.
For education and evidence exploration, not diagnosis or individualized medical advice.