Microbiome
Gut microbiome diversity
A family of metrics describing within-sample microbial diversity.
What it measures
Number and distribution of microbial taxa detected in a stool sample.
Why it matters
Microbiome composition is associated with diet, disease and aging phenotypes in research.
How to interpret it
Interpret only with the sequencing method, reference population and ecological context.
Important limitations
Higher diversity is not universally healthier; stool profiles are variable and consumer interpretations can overreach evidence.
Evidence status
Research-stage biomarker
Active research area; no validated general-purpose biological-age or longevity target.
Research & guidance
Original papers, validation studies, reviews and clinical guidance connected to this measurement.
systematic review / meta-analysis of RCTs
Effects of Polyphenol Supplementation on Gut Microbiota Composition and Fecal Short-Chain Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients · 2026
Interventions can shift microbiome and fecal SCFA measures, but these changes should not be assumed to represent clinically meaningful longevity benefits.
systematic review
The Gut Microbiome, Aging, and Longevity: A Systematic Review
Nutrients · 2020
Human aging studies show microbiome composition and functional differences, but cross-sectional designs and inconsistent taxonomic findings limit individual interpretation.
For education and evidence exploration, not diagnosis or individualized medical advice.