Biological aging
DNA methylation age
An algorithmic estimate derived from DNA methylation patterns.
What it measures
Selected methylation sites combined into an aging-clock model.
Why it matters
Some clocks predict chronological age; newer clocks are trained on morbidity, mortality or aging pace.
How to interpret it
Interpret only with the specific clock, tissue, cohort and outcome it was validated against.
Important limitations
Different clocks measure different constructs; clinical utility and use as surrogate endpoints remain unestablished.
Evidence status
Research-stage biomarker
Active and important aging-biomarker research field, but not yet a general clinical measure of aging.
Research & guidance
Original papers, validation studies, reviews and clinical guidance connected to this measurement.
For education and evidence exploration, not diagnosis or individualized medical advice.