{
  "dataset": "AgeBeacon Open Human Longevity Evidence Dataset",
  "version": "v1.0",
  "released": "2026-10-02",
  "methodology_version": "microbiome-supplements-v1-qc2",
  "record_count": 57,
  "interpretation": "Registry-level evidence map; inclusion does not indicate efficacy.",
  "records": [
    {
      "title": "OsteoPreP: Food Supplements for Postmenopausal Bone Health",
      "status": "UNKNOWN",
      "masking": "TRIPLE",
      "relevance": "DIRECT",
      "enrollment": 160,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05348694",
      "registry_id": "NCT05348694",
      "intervention": "Akkermansia muciniphila",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Evaluation of HB05P for Muscle Strength Improvement in Older Adults",
      "status": "COMPLETED",
      "masking": "TRIPLE",
      "relevance": "DIRECT",
      "enrollment": 80,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07402278",
      "registry_id": "NCT07402278",
      "intervention": "Akkermansia muciniphila",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "HB05P on Muscle Health",
      "status": "RECRUITING",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 80,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07749118",
      "registry_id": "NCT07749118",
      "intervention": "Akkermansia muciniphila",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The Effects of a High Protein Diet on Microbiota, Gastrointestinal Function and Wellness in Older Women",
      "status": "COMPLETED",
      "masking": "TRIPLE",
      "relevance": "DIRECT",
      "enrollment": 29,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT02445560",
      "registry_id": "NCT02445560",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "GOS and Microbial Fermentation in Aging",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "DIRECT",
      "enrollment": 44,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT03077529",
      "registry_id": "NCT03077529",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The Correlation and Intervention of Intestinal Flora and Frailty in the Elderly",
      "status": "UNKNOWN",
      "masking": "DOUBLE",
      "relevance": "DIRECT",
      "enrollment": 300,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT03995342",
      "registry_id": "NCT03995342",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "DIRECT",
      "enrollment": 71,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT04309292",
      "registry_id": "NCT04309292",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "OsteoPreP: Food Supplements for Postmenopausal Bone Health",
      "status": "UNKNOWN",
      "masking": "TRIPLE",
      "relevance": "DIRECT",
      "enrollment": 160,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05348694",
      "registry_id": "NCT05348694",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Dietary Strategy to Tackle Sarcopenia in Early Elderly Subjects (FOOP-Sarc)",
      "status": "COMPLETED",
      "masking": "TRIPLE",
      "relevance": "DIRECT",
      "enrollment": 39,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05485402",
      "registry_id": "NCT05485402",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effects of β-glucans on Gut Permeability and Microbiota in Elderly",
      "status": "COMPLETED",
      "masking": "TRIPLE",
      "relevance": "DIRECT",
      "enrollment": 43,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05584254",
      "registry_id": "NCT05584254",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Microbiota-Inflammation-Brain Axis in Heart Failure: New Functional Food for the Prevention of undeRnutrition in Older",
      "status": "RECRUITING",
      "masking": "NONE",
      "relevance": "DIRECT",
      "enrollment": 60,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07076329",
      "registry_id": "NCT07076329",
      "intervention": "Prebiotics",
      "quality_band": "MODERATE",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults",
      "status": "RECRUITING",
      "masking": "NONE",
      "relevance": "DIRECT",
      "enrollment": 40,
      "randomized": false,
      "source_url": "https://clinicaltrials.gov/study/NCT07454616",
      "registry_id": "NCT07454616",
      "intervention": "Prebiotics",
      "quality_band": "LOW",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "PRIMAGE (Probiotics, Immunity and Ageing)",
      "status": "UNKNOWN",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 120,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT01066377",
      "registry_id": "NCT01066377",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The Effect of Prebiotic B-GOS on the Immune Function, Metabolism and Gut Microbiota of Elderly People",
      "status": "COMPLETED",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 40,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT01303484",
      "registry_id": "NCT01303484",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 22,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT01304771",
      "registry_id": "NCT01304771",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effects of MSPrebiotic on Gut Health in the Elderly",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 84,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT01977183",
      "registry_id": "NCT01977183",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Prebiotic Supplementation and Intestinal Barrier Function in Elderly: a RCT",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 60,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT03336385",
      "registry_id": "NCT03336385",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The RAMP Study - Rejuvenation of the Aging Microbiota With Prebiotics",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 98,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT03690999",
      "registry_id": "NCT03690999",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effects of Triphala and VSL#3 Probiotic Supplementation on Stool Microbiome Profiles and Inflammation",
      "status": "TERMINATED",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 75,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT03907501",
      "registry_id": "NCT03907501",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": true,
      "results_publication_present": false
    },
    {
      "title": "Effect of MSPrebiotic on Gastrointestinal Function and Blood Glucose Levels",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 110,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT03910153",
      "registry_id": "NCT03910153",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Creatine-Guanidinoacetic Acid Supplementation for Sarcopenia (CREGAAS)",
      "status": "COMPLETED",
      "masking": "DOUBLE",
      "relevance": "INDIRECT",
      "enrollment": 30,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT04652921",
      "registry_id": "NCT04652921",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Yogurt Supplementation to Alter Bone Biomarkers, the Gut Microbiota and Inflammation in Older Adults",
      "status": "TERMINATED",
      "masking": "NONE",
      "relevance": "INDIRECT",
      "enrollment": 33,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05350579",
      "registry_id": "NCT05350579",
      "intervention": "Prebiotics",
      "quality_band": "MODERATE",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Design and Development of a Novel Food Supplement for Osteoporosis Based on Gut Microbiome Mechanisms",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 117,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05421819",
      "registry_id": "NCT05421819",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effect of the Administration of a Symbiotic (E. Faecium and Agave Inulin) on Mild Cognitive Impairment in Older Adults",
      "status": "UNKNOWN",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 48,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05688618",
      "registry_id": "NCT05688618",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The Effect of GI Biome #7 on Gut Microbiome and Health of the Elderly",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 60,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05735418",
      "registry_id": "NCT05735418",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Exploring Mechanism of Action of Dietary Fibre on the Gut Microbiota and Metabolites",
      "status": "COMPLETED",
      "masking": "DOUBLE",
      "relevance": "INDIRECT",
      "enrollment": 40,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT05906589",
      "registry_id": "NCT05906589",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Biomarker Identification and Nutritional Intervention of Primary Sarcopenia Based on Gut-muscle Axis",
      "status": "UNKNOWN",
      "masking": "DOUBLE",
      "relevance": "INDIRECT",
      "enrollment": 120,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT06347835",
      "registry_id": "NCT06347835",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Gut-brain Health Effects of PREbiotics in Older Adults With Suspected COgnitive DEcline",
      "status": "ACTIVE_NOT_RECRUITING",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 164,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT06433037",
      "registry_id": "NCT06433037",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effect of an Oral Nutritional Supplement (ONS) with Prebiotic Fibre Compared to a Non-fibre Containing ONS Equal in Energy and Protein Content on Gut Microbiota in Older Adults with or At Risk of Disease Related Malnutrition",
      "status": "NOT_YET_RECRUITING",
      "masking": "DOUBLE",
      "relevance": "INDIRECT",
      "enrollment": 62,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT06645171",
      "registry_id": "NCT06645171",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "BiomeBakery Project",
      "status": "COMPLETED",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 55,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT06796712",
      "registry_id": "NCT06796712",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Supplementation of Inulin + L. Acidophilus in Elders with T2DM",
      "status": "NOT_YET_RECRUITING",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 48,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT06830824",
      "registry_id": "NCT06830824",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis",
      "status": "NOT_YET_RECRUITING",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 84,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07189585",
      "registry_id": "NCT07189585",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women",
      "status": "RECRUITING",
      "masking": "NONE",
      "relevance": "INDIRECT",
      "enrollment": 30,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07222111",
      "registry_id": "NCT07222111",
      "intervention": "Prebiotics",
      "quality_band": "MODERATE",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight",
      "status": "RECRUITING",
      "masking": "QUADRUPLE",
      "relevance": "INDIRECT",
      "enrollment": 90,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07453823",
      "registry_id": "NCT07453823",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effects of a 6-months Fiber- and Polyphenol-rich Diet on Brain Inflammatory Processes in Perimenopausal Women Living With Overweight or Obesity",
      "status": "RECRUITING",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 120,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07501377",
      "registry_id": "NCT07501377",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "The BALANCE Study - Improving Glucose Control Through Prebiotic Gut Health Drink in Postmenopausal Women",
      "status": "NOT_YET_RECRUITING",
      "masking": "TRIPLE",
      "relevance": "INDIRECT",
      "enrollment": 30,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07565675",
      "registry_id": "NCT07565675",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)",
      "status": "RECRUITING",
      "masking": "DOUBLE",
      "relevance": "INDIRECT",
      "enrollment": 84,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07592975",
      "registry_id": "NCT07592975",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment",
      "status": "RECRUITING",
      "masking": "DOUBLE",
      "relevance": "INDIRECT",
      "enrollment": 20,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT07818369",
      "registry_id": "NCT07818369",
      "intervention": "Prebiotics",
      "quality_band": "HIGH",
      "quality_version": "microbiome-supplements-v1",
      "registry_source": "ctgov",
      "results_available": false,
      "results_publication_present": false
    },
    {
      "title": "New E-Service for a Dietary Approach to the Elderly",
      "status": "COMPLETED",
      "masking": "NONE",
      "relevance": "INDIRECT",
      "enrollment": 48,
      "randomized": true,
      "source_url": "https://clinicaltrials.gov/study/NCT01179789",
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      "title": "Synbiotic to Attenuate Resorption of the Skeleton",
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      "title": "A Study to Evaluate the Effects of the Combination of GI-102 With GIB-7 on Biomarkers of Aging in Healthy Adults and Cancer Survivors",
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    {
      "title": "The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight",
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    {
      "title": "Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment",
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}